李丁

中山大学教授

李丁，男，博士，2009年由中山大学‘百人计划’引入中山大学药学院担任教授、博士生导师。兼任教育部学位中心学位论文评议专家和广东省药学会药物化学专业委员会委员。

研究方向

抗癌领域研究，包括小分子化合物通过调控基因启动子区域特殊DNA二级结构及其结合蛋白进而影响下游癌基因表达的分子机制、以小分子化合物为探针的端粒G-四链体及其结合蛋白Shelterin相互作用机制研究等。另外，还从事心血管疾病和老年痴呆症相关的一些分子机制研究。

人物经历

教育经历

北京大学化学系1985.9--1989.8本科毕业

美国明尼苏达大学化学系1990.9--1995.4博士毕业

工作经历

1990--1995 研究和教学助理，美国明尼苏达大学，化学系

1995--1996 研究助理，美国哈佛大学，化学系

1996--2000 博士后，美国德州农工大学，化学系

2000--2002 助理教授，香港城市大学，生物化学系

2002--2009 副教授，香港城市大学，生物化学系

2009—教授，博士生导师，中山大学，药学院

教授课程

化学生物学、药物化学，有机化学。

社会兼职

教育部学位中心学位论文评议专家

广东省药学会药物化学专业委员会委员

学术成果

科研项目

代表性论文

1.“Syntheses and evaluation of new acridone derivatives for selective binding of oncogene c-myc promoter i-motifs in gene transcriptional regulation” Shu, B.; Cao, J.; Kuang, G.; Qiu, J.; Zhang, M.; Zhang, Y.; Wang, M.; Li, X.; Kang, S.; Ou, T.-M.; Tan, J.-H.; Huang, Z.-S.;Li, D.*Chem. Comm.2018,54, 2036-2039.（杂志影响因子6.319）

2.“Interaction of Quindoline derivative with telomeric repeat-containing RNA induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2”Zhang, Y.; Zeng, D.; Cao, J.; Wang, M.; Shu, B.; Kuang, G.; Ou, T.-M.; Tan, J.-H.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Biochim. Biophys. Acta - General Subjects2017,1861 (12), 3246-3256.（杂志影响因子4.702）

3.“Curcusone C induces telomeric DNA-damage response in cancer cells through inhibition of telomeric repeat factor 2” Wang, M.; Cao, J.; Zhu, J.-Y.; Qiu, J.; Zhang, Y.; Shu, B.; Ou, T.-M.; Tan, J.-H.; Gu, L.-Q.; Huang, Z.-S.; Yin, S.;Li, D.*Biochim. Biophys. Acta -Proteins Proteomics2017,1865 (11), 1372-1382.

4. “Role of hairpin-quadruplex DNA secondary structural conversion in the promoter of hnRNP K in gene transcriptional regulation” Qiu, J.; Liu, J.; Chen, S.; Ou, T.-M.; Tan, J.-H.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Org. Lett.2015,17(18), 4584-4587.（杂志影响因子6.579）

5.“Cp*Rh(III) and Cp*Ir(III)-catalysed redox-neutral C-H arylation with quinone diazides: quick and facile synthesis of arylated phenols” Zhang, S.-S.; Jiang, C.-Y.; Li, Q.; Huang, Z.-S.;Li, D.;* Wang, H*Chem. Comm.2015,51, 10240-10243.

6.“Biological function and medicinal research significance of G-quadruplex interactive proteins” Qiu, J.; Wang, M.; Zhang, Y.; Zeng, P.; Ou, T.-M.; Tan, J.-H.; Huang, S.-L.; An, L.-K.; Wang, H.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Curr. Top. Med. Chem.2015,15 (19), 1971-1987.

7.“Mechanistic studies on the anticancer activity of 2,4-disubstituted quinazoline derivative” Su, L.; Zheng, H.; Li, Z.; Qiu, J.; Chen, S.; Liu, J.; Ou, T.-M.; Tan, J.-H.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Biochim. Biophys. Acta - General Subjects2014,1840, 3123-3130.

8.“Mechanistic studies for tri-targeted inhibition of enzymes involved in cholesterol biosynthesis by green tea polyphenols” Ge, H.;Liu, J.; Zhao, W.; Wang, Y.; He, Q.; Wu, R.;Li, D.*; Xu, J.*Org. Biomol. Chem.2014,12, 4941-4951. (Highlighted by Chemistry World; a. The first two authors contributed equally to this work)

9.“Cellular nucleic acid binding protein suppresses tumor cell metastasis and induces tumor cell death by downregulating heterogeneous ribonucleoprotein K in fibrosarcoma cells” Qiu, J.; Chen, S.; Su, L.; Liu, J.; Xiao, N.; Ou, T.-M.; Tan, J.-H.; Gu, L.-Q.*; Huang, Z.-S.*;Li, D.*Biochim. Biophys. Acta - General Subjects2014,1840, 2244-2252.

10.“G-quadruplex-mediated regulation of telomere binding protein POT1 gene expression” He, Q.; Zeng, P.; Tan, J.-H.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Biochim. Biophys. Acta - General Subjects2014,1840, 2222-2233.

11.“Synthesis and characterization of 1H-phenanthro[9,10-d]imidazole derivatives as multifunctional agents for treatment of Alzheimer's disease” Liu, J.; Qiu, J.; Wang, M.; Wang, L.; Su, L.; Gao, J. Gu, Q.; Xu, J.; Huang, S.-L.; Gu, L.-Q.; Huang, Z.-S.*;Li, D.*Biochim. Biophys. Acta - General Subjects2014,1840, 2886-2903.

12.“Syntheses and characterization of non-bisphosphonate quinoline derivatives as new FPPS inhibitors” Liu, J.; Liu, W.; Ge, H.; Gao, J.; He, Q.; Su, L.; Xu, J.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Biochim. Biophys. Acta - General Subjects2014,1840,1051-1062.

13.“Mechanistic studies for the role of cellular nucleic-acid-binding protein (CNBP) in regulation of c-myc transcription” Chen, S.; Su, L.; Qiu, J.; Xiao, N.; Lin, J.; Tan, J.-H.; Ou, T.-M.; Gu, L.-Q.*; Huang, Z.-S.*;Li, D.*Biochim. Biophys. Acta - General Subjects2013,1830,4769-4777.

14.“Multi-target-directed design, syntheses, and characterization of fluorescent bisphosphonate derivatives as multifunctional enzyme inhibitors in mevalonate pathway” Gao, J.; Liu, J.; Qiu, Y.; Chu, X.; Qiao, Y;Li, D.*Biochim. Biophys. Acta - General Subjects2013,1830, 3635-3642. featured online on Global Medical Discovery [ISSN 1929-8536]

15.“Interaction of berberine derivative with protein POT1 affect telomere function in cancer cells” Xiao, N.; Chen, S.; Ma, Y.; Qiu, J.; Tan, J.-H.; Ou, T.-M.; Gu, L.-Q.; Huang, Z.-S.;Li, D.*Biochem. Biophys. Res. Comm.2012,419 (3), 567-572.（featured online on Global Medical Discovery [ISSN 1929-8536]

16.“Disubstituted quinazoline derivatives as a new type of highly selective ligands for telomeric G-quadruplex DNA” Li, Z.; Tan, J.-H.; He, J.-H.; Long, Y.; Ou, T.-M.;Li, D.*; Gu, L.-Q.; Huang, Z.-S.*Euro. J. Med. Chem.2012,47, 299-311.

17.“Design, synthesis, and characterization of piperazinedione-based dual protein inhibitors for both farnesyltransferase and geranylgeranyltransferase-I” Qiao, Y.; Gao, J.; Qiu, Y.; Wu, L.; Guo, F.; Lo, K.-W.;Li, D.*Euro. J. Med. Chem.2011,46, 2264-2273.

18.“Discovery of potent inhibitor for farnesyl pyrophosphate synthase in mevalonate pathway” Gao, J.; Chu, X.; Qiu, Y.; Wu, L.; Qiao, Y.; Wu, J.;Li, D.*Chem. Comm.2010,46, 5340-5342.

19.“Oct-2-en-4-ynoyl-CoA as a specific inhibitor of acyl-CoA oxidase” Zeng, J.; Wu, L.; Zhang, X.; Liu, Y.; Deng, G.;Li, D.*Org. Lett.2008,10 (19), 4287-4290.

20.“Comparative inhibition studies of enoyl-CoA hydratase 1 and enoyl-CoA hydratase 2 in long-chain fatty acid oxidation” Wu, L.; Lin, S.;Li, D.*Org. Lett.2008,10 (15), 3355-3358.

21.“Oct-2-yn-4-enoyl-CoA as a multifunctional enzyme inhibitor in fatty acid oxidation” Wu, L.; Liu, X.;Li, D.*Org. Lett.2008,10 (11), 2235-2238.

22.“Inactivation of thiolase by 2-alkynoyl-CoA via its intrinsic isomerase activity” Wu, L.; Zeng, J.; Deng, G.; Guo, F.; Li, N.; Liu, X.; Chu, X.;Li, D.*Org. Lett.2007,9(20), 3877-3880.

23.“Bifunctional inhibitors of mevalonate kinase and mevalonate 5-diphosphate decarboxylase” Qiu, Y.;Li, D.*Org. Lett.2006,8(6), 1013-1016.

24.“Intrinsic isomerase activity of medium-chain acyl-CoA dehydrogenase” Zeng, J.;Li, D.*Biochemistry2005,44 (17), 6715-6722.

25.“Crystal structure of precorrin-8x methyl mutase” Shipman, L.*;Li, D.; Roessner, C.; Scott, A.; Sacchettini, J.*Structure2001,9 (7), 587-596. (a. The first two authors contributed equally to this work)（杂志影响因子4.945）

26.“The toxicity of methylenecyclopropylglycine: studies of the inhibitory effects of (methylenecyclopropyl)formyl-CoA on enzymes involved in fatty acid metabolism and the molecular basis of its inactivation of enoyl-CoA hydratases”Li, D.; Agnihotri, G.; Dakoji, S.; Oh, E.; Lantz, M.; Liu, H.-w.*J. Am. Chem. Soc.1999,121 (39), 9034-9042.（杂志影响因子13.858）

27.“Spiropentylacetyl-CoA, a mechanism-based inactivator of acyl-CoA dehydrogenases”Li, D.; Zhou, H.-q.; Dakoji, S.; Shin, I.; Oh, E.; Liu, H.-w.*J. Am. Chem. Soc.1998,120 (9), 2008-2017.

28.“Mechanistic studies of the inactivation of crotonase by (methylenecyclopropyl)-formyl-CoA”Li, D.; Guo, Z.; Liu, H-w.*J. Am. Chem. Soc.1996,118 (1), 275-276.

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