杨维东

暨南大学教授

杨维东，博士，教授，博士生导师。《生态毒理学报》编委，广东省高等学校生物类教学指导委员会委员兼秘书长。主要从事环境生物对毒素的响应与抗性机制、赤潮毒素的生态效应与致毒机理、有毒有害藻的遗传多样性等的研究。近年连续主持国家自然科学基金面上项目4项，以通讯作者身份在Fish Shellfish Immunol、Aquat Toxicol、Environ Pollut、Algal Res等期刊发表SCI论文30余篇，授权发明专利4项。出版《微量元素与健康》、《环境生理学》等教材、专著多部，获教育部高等学校科学研究优秀成果奖（科学技术）二等奖1项，广东省教育教学成果一等奖2项、二等奖1项。

人物经历

学习经历

1989年本科毕业于西北师范大学化学系

1992年在西北师范大学化学系获得理学硕士学位

1999年在中山大学化学化工学院获得理学博士学位

工作经历

1992-1996在兰州大学药学院（原兰州医学院药学系）任教

1999年入职暨南大学生命科学技术学院，先后任讲师、副教授（2000）、教授（2006）。

研究方向

1、环境生物对赤潮毒素的响应与抗性机制

2、赤潮毒素的生态效应、毒性与致毒机理

3、有毒有害藻的遗传多样性

科研成果

主要论文

[1]Yu-hu Jiao, Meng Liu, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang, Wei-dong Yang*, 2019. EMT is the major target for okadaic acid-suppressed the development of neural crest cells in chick embryo. Ecotoxicology and Environmental Safety 180, 192–201.

[2]Zheng-bingHe,Guo-fangDuan,Cai-yingLiang,Hong-yeLi,Jie-shengLiu,Wei-dongYang∗, 2019.Up-regulation of Nrf2-dependent antioxidant defenses inPerna viridisafter exposed toProrocentrum lima.Fish and Shellfish Immunolog 90, 173–179.

[3]Xiao-Meng Wei, Mi-Yu Lu, Guo-Fang Duan, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2019. Responses of CYP450 in the mussel Perna viridis after short-term exposure to the DSP toxins-producing dinoflagellate Prorocentrum lima.Ecotoxicology and Environmental Safety 176, 178–185.

[4]Song Gu, Shao-Wen Xiao, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu and Wei-Dong Yang*, 2019. ABC transporters in Prorocentrum lima and their expression under different environmental conditions including okadaic acid production. Mar. Drugs 17, 259.

[5]Jian-wei Zheng, Su-li Liu, Song-Hui Lu, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018. Proteomic profile in the mussel Perna viridis after short-term exposure to the brown tide alga Aureococcus anophagefferens. Ecotoxicology and Environmental Safety 162, 365–375

[6]Dao-yi Hou, Xiao-tong Mao, Song Gu, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2018, Systems-level analysis of metabolic mechanism following nitrogen limitation in benthic dinoflagellate Prorocentrum lima. Algal Research 33, 389–398.

[7]Yu-hu Jiao, Min Dou, Guang Wang, Hong-ye Li, Jie-sheng Liu, Xuesong Yang*, Wei-dong Yang*, 2017. Exposure of okadaic acid alters the angiogenesis in developing chick embryos. Toxicon 133, 74-81.

[8]Dao-yi Hou, Jin-jin Liang, Cheng Zou, Hong-ye Li, Jie-sheng Liu, Wei-dong Yang*, 2016. MRP functional activity and character in the dinoflagellate Prorocentrum lima. J Appl Phycol28(3), 1667–1676.

[9]Fei Liu, He Zheng-Bing, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2016. Inhibition of five natural products from Chinese herbs on the growth of Chattonella marina. Environ Sci Pollut Res 23(17), 17793-17800.

[10]Yue Li, Hong-jia Huang, Hongye Li, Jiesheng Liu, Weidong Yang*, 2016. Genetic diversity of Ulva prolifera population in Qingdao coastal water during the green algal blooms revealed by microsatellite.Marine Pollution Bulletin111, 237-246.

[11]Lu Huang, Su-Li Liu, Jian-Wei Zheng, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015.P-glycoprotein and its inducible expression in three bivalve species after exposure to Prorocentrum lima. Aquatic Toxicology169, 123-132.

[12]Jin-Jin Liang, Yun-Hui Li, Fei Liu, Hong-Ye Li, Jie-Sheng Liu, Wei-Dong Yang*, 2015.Experimental removal of Alexandrium tamarense cells using sulfobetaines and their modified clays. J Appl Phycol 27(6), 2313-2319.

[13]Jian Chen, Qian Ye, Hai-Feng Gu, Hong-Ye Li, Song-Hui Lv, Jie-Sheng Liu, Wei-Dong Yang*, 2015. Variability in the allelopathic action of the Alexandrium tamarense species complex along the coast of China. Harmful Algae 47, 17–26.

[14]Lin-Xi Dang, Yue Li, Fei Liu, Yong Zhang, Wei-Dong Yang, Hong-Ye Li, Jie-Sheng Liu, 2015.Chemical response of the toxic dinoflagellate Karenia mikimotoi against grazing by three species of zooplankton. J Eukaryot Microbiol 62, 470–480.

[15]Lu Huang, Ying Zou, Hui-wen Weng, Hong-Ye Li , Jie-Sheng Liu, Wei-Dong Yang*, 2015. Proteomic profile in Perna viridis after exposed to Prorocentrum lima, a dinoflagellate producing DSP toxins. Environmental Pollution 196, 350-357.

[16]Lu Huang,Jie Wang,Wen-Chang Chen,Hong-Ye Li,Jie-Sheng Liu,TaoJiang,Wei-Dong Yang*, 2014. P-glycoprotein expression inPerna viridisafter exposure toProrocentrum lima, a dinoflagellate producing DSP toxins. Fish Shellfish Immunol 39(2), 254–262.

[17]Cheng Zou,Rui-Min Ye,Jian-Wei Zheng,Zhao-He Luo,Hai-Feng Gu,Wei-Dong Yang,Hong-Ye Li,Jie-Sheng Liu,2014.Molecular phylogeny and PSP toxin profile of the Alexandrium tamarense species complex along the coast of China.Marine Pollution Bulletin89, 209–219.

[18]Yan-yan Xu, Jin-Jin Liang,Wei-Dong Yang*, Jie Wang, Hong-Ye Li, Jie-Sheng Liu, 2014. Cloning and expression analysis of P-glycoprotein gene in Crassostrea ariakensis. Aquaculture418–419, 39–47.

主要著作

1、杨维东，刘洁生，彭喜春. 微量元素与健康, 武汉: 华中科技大学出版社，2007

2、齐雨藻等著.南海赤潮研究.广州:广东经济出版社, 2008 (撰写：赤潮毒素及其毒理学)

3、刘洁生,朱伟杰,王子栋.环境生理学.北京:科学出版社, 2011. (参编)

承担课题

1、国家自然科学基金面上项目：贝类Nrf2/ARE信号通路参与腹泻性贝毒代谢解毒的分子机制（41776120），2018.1-2021.12, 69万（直接经费），主持.

2、国家自然科学基金面上项目：双壳贝类细胞色素P450及其在腹泻性贝毒代谢解毒机制中的作用研究（41576116），2016.1-2019.12, 69万（直接经费），主持.

3、国家自然科学基金面上项目：中国沿海典型产毒甲藻塔玛亚历山大藻的遗传多样性与种源分析（41176088），2012.1-2015.12，69万，主持。

4、国家自然科学基金面上项目：p-糖蛋白在双壳贝类抗腹泻性贝毒中的作用机制研究（40976065），2010.1-2012.12，44万，主持。

发明专利

1、李宏业，朱聪聪，杨维东，刘洁生，一种海洋微藻叶绿体转化载体及其应用，2012.7.18，中国，ZL 201010285197.X

2、杨维东，李赟辉，李宏业，刘洁生，一种甜菜碱衍生物改性粘土及其制备方法和应用，2015.2.18，中国，201310087281.4