范建华

华东理工大学教授、博士生导师

1984年12月生，江苏海门人，中共党员，教授，博士生导师。

人物经历

研究方向

（1）生物转化与绿色低碳技术

主要针对富含生物活性物质和高效环境修复的微藻优良种质，重点探索营养与环境因素对微藻生长及代谢作用机制、微藻光合自养和光暗发酵过程中碳氮磷高效生物转化及优化调控技术，为微藻植物蛋白和生物活性物质生产（如藻胆蛋白、PUFAs、色素、多糖等）、环境治理（CO2减排和污染物降解）与生物质利用、生物饵料与饲料、生物能源的开发提供绿色低碳关键技术。

（2）合成生物系统构建与应用

主要以微藻及蓝细菌等光合微生物为研究对象，基于功能基因组学、代谢途径解析与组装、合成生物技术等手段开发藻细胞底盘，建立成熟的表达系统/基因编辑体系（细胞核、叶绿体基因组），实现外源蛋白（如疫苗、工业酶、药用蛋白、抗体、细胞因子等）在藻细胞内高效表达，藉此推动微藻绿色细胞工厂相关技术的发展（如重组微藻疫苗、活细胞光-酶催化等），实现高值化利用。

学术兼职

1. Frontiers in Marine Science副主编（SCI收录，Q1 Top期刊，2019-至今）

2. Bioresources and Bioprocessing青年编委（SCI收录，Q2，2020-至今）

3. Frontiers in Bioengineering and Biotechnology客座副主编（SCI收录，Q2），主持Novel insights into algal biology and biotechnology（2017）、Advanced technologies and perspectives on sustainable microalgae production（2020）、Microalgal production of omega fatty acids: present and future（2022）专刊

4. 中国生物工程学会一碳生物技术专委会委员（2022-2026）

5. 中国化工学会生物化工专业委员会青年学者工作委员会委员（2023-2027）

6. 上海市生物工程学会一碳生物技术专委会委员（2023-2027）

7. 美国植物生物学家学会（ASPB）会员（2015-）、中国藻业协会会员（2020-）

8. Nature Communications、New Phytologist、Biotechnology for Biofuels、Bioresource Technology、Journal of Agricultural and Food Chemistry、Biotechnology Journal、Biochemical Engineering Journal、Briefings in Bioinformatics、Algal Research、生物工程学报、微生物学报等20多个期刊审稿人

教学情况

获中国石油与化工教育教学优秀成果一等奖（2020，2022），华东理工大学本科教学成果二等奖（2019，2021），主持教育部产学合作协同育人项目（2019，2021）。指导本科生获国际遗传工程机器大赛iGEM金奖及生物制造单项最佳奖（2019）；指导本科生获全国大学生生命科学竞赛一等奖（2021，2项）；指导研究生获中国“互联网+”大学生创新创业大赛上海市金奖（2021）、“挑战杯”中国大学生创业计划竞赛上海市银奖等省部级奖励（2022）。指导研究生获国家奖学金（5人次）、上海市优秀毕业生（5人次）、成思危名誉校长奖学金和校高水平论文奖等荣誉；指导本科生承担国家级/上海市级“大学生创新创业训练计划”十多项。

承担教学任务：

1. 上海市重点课程、专业必修课《分子生物学》（全英文，48学时，3学分）；

2. 专业选修课《进化生物学》（32学时，2学分）；

3. 专业必修课《生物化学实验》（32学时，1学分）；

4. 公选课《国际遗传工程机器竞赛与合成生物技术》（16学时，1学分，团队教学）；

5. 班导师，iGEM竞赛指导老师，Biomaker创新俱乐部指导老师，大创指导老师；

发表论文

[1] Ping Wu, Tianyouzi Hu, Liyun Sun, Jianhua Fan*. Efficient degradation of sulfadiazine by photosynthetic cyanobacteria Synechocystis sp. PCC 6803 coupling with recombinant laccase strategy. Chemical Engineering Journal, 2023, 474, 145974. IF15.10, 1区top

[2] Cheng Chen, Qianwen Shi, Akang Tong, Liyun Sun, Jianhua Fan*. Screening of microalgae strains for efficient biotransformation of small molecular organic acids from dark fermentation biohydrogen production wastewater. Bioresource Technology, 2023, 390, 129872. IF11.39, 1区top

[3] Qianwen Shi#, Zuodong Zhou#, Zhiwei Hong, Zhi Yang, Zhengquan Gao, Liyun Sun*, Jianhua Fan*.Transcriptomics reveal how circadian regulation contributes to starch hyperaccumulation in marine alga Tetraselmis helgolandica. GCB Bioenergy, 2023, 15:1477-1493. IF5.59, 3区

[4] Liang Ji#, Sheng Qiu#, Zhiheng Wang, Chenni Zhao, Bo Tang, Zhengquan Gao, Jianhua Fan*. Phycobiliproteins from algae: Current updates in sustainable production and applications in food and health. Food Research International, 2023,167:112737. IF8.10, 1区top

[5] Sheng Qiu, Yuchen Yuan, Xiaoyi Li, Chenni Zhao, Yulong He, Bo Tang, Wenda Wang, Jianhua Fan*. Peridinin-chlorophyll-protein complex industry from algae: A critical review of the current advancements, hurdles, and biotechnological potential. Algal Research, 2023, 72, 103118. IF5.10, 2区

[6] Cheng Chen, Tao Tang, Qianwen Shi, Zuodong Zhou, Jianhua Fan*. The potential and challenge of microalgae as promising future food sources. Trends in Food Science and Technology, 2022, 126:99-112. IF15.29, 1区top，ESI高被引、热点论文

[7] Qianwen Shi, Cheng Chen, Tingwei He, Jianhua Fan*. Circadian rhythm promotes the biomass and amylose hyperaccumulation by mixotrophic cultivation of marine microalga Platymonas helgolandica. Biotechnology for Biofuels and Bioproducts, 2022, 15, 75. IF6.29, 2区

[8] Liang Ji, Yueling Liu, Jianquan Luo, Jianhua Fan*. Freeze-thaw-assisted aqueous two-phase system as a green and low-cost option for analytical grade B-phycoerythrin production from unicellular microalgae Porphyridium purpureum. Algal Research, 2022, 67, 102831. IF5.1, 2区

[9] Ke Ma, Lei Deng, Haizhen Wu*, Jianhua Fan*. Towards green biomanufacturing of high-value recombinant proteins using promising cell factory: Chlamydomonas reinhardtii chloroplast. Bioresources and Bioprocessing, 2022, 9, 83. IF4.60, 3区

[10] Dongqing Zhou, Yeling Luo, Yingqiu Zhang, Chenni Zhao, Hui Wu*, Jianhua Fan*. Perturbing electron carriers of green algae Chlamydomonas reinhardtii for efficient physiological and metabolic regulation. Food Bioengineering, 2022, 1:148-158.

[11] Ping Wu, Zhaofei Zhang, Yeling Luo, Yunpeng Bai, Jianhua Fan*. Bioremediation of phenolic pollutants by algae - current status and challenges. Bioresource Technology, 2022, 350, 126930. IF11.39, 1区top

[12] Ke Ma, Siwei Chen, Yue Wu, Yiting Ma, Haochen Qiao, Jianhua Fan*, Haizhen Wu*. Dietary supplementation with microalgae enhances the zebrafish growth performance by modulating immune status and gut microbiota. Applied Microbiology and Biotechnology, 2022, 106: 773-788. IF5.00, 3区

[13] Jianhua Fan, Yinghui Zhang, Ping Wu, Xiaoyan Zhang, Yunpeng Bai*. Enhancing cofactor regeneration of cyanobacteria for the light-powered synthesis of chiral alcohols. Bioorganic Chemistry, 2022, 118, 105477. IF5.10, 2区top

[14] Jianhua Fan*, Qiuwen Bao, Ke Ma, Xiaofei Li, Jing Jia, Haizhen Wu*. Antioxidant and innate immunity of Danio rerio against Edwardsiella tarda in response to diets including three kinds of marine microalgae. Algal Research, 2022, 64, 102689. IF5.10, 2区

[15] Jianhua Fan, Dongqing Zhou, Cheng Chen, Ju Wu, Hui Wu*. Reprogramming the metabolism of Synechocystis PCC 6803 by regulating the plastoquinone biosynthesis. Synthetic and Systems Biotechnology, 2021, 4(6):351-359. IF4.80, 2区

[16] Liang Ji, Shaohua Li, Cheng Chen, Haojie Jin, Haizhen Wu, Jianhua Fan*. Physiological and transcriptome analysis elucidates the metabolic mechanism of versatile Porphyridium purpureum under nitrogen deprivation for exopolysaccharides accumulation. Bioresources and Bioprocessing, 2021, 8, 73. IF4.60, 3区

[17] Shaohua Li#, Jianke Huang#, Liang Ji, Cheng Chen, Ping Wu, Wei Zhang, Gaoyi Tan, Haizhen Wu, Jianhua Fan*. Assessment of light distribution model for marine red microalga Porphyridium purpureum for sustainable production in photobioreactor. Algal Research, 2021, 58, 102390. IF5.10, 2区

[18] Qianwen Shi, Cheng Chen, Wei Zhang, Ping Wu, Meng Sun, Hui Wu, Haizhen Wu, Pengcheng Fu*, Jianhua Fan*. Transgenic eukaryotic microalgae as green factories: providing new ideas for the production of biologically active substances. Journal of Applied Phycology, 2021, 33:705-728. IF3.30, 3区

[19] Ke Ma#, Qiuwen Bao#, Yue Wu, Siwei Chen, Shuxin Zhao, Haizhen Wu*, Jianhua Fan*. Evaluation of microalgae as immunostimulants and recombinant vaccines for disease prevention and control in aquaculture. Frontiers in Bioengineering and Biotechnology, 2020, 8, 590431. IF5.69, 3区

[20] Shaohua Li, Liang Ji, Cheng Chen, Shuxin Zhao, Meng Sun, Zhengquan Gao, Haizhen Wu, Jianhua Fan*.Efficient accumulation of high-value bioactive substances by carbon to nitrogen ratio regulation in marine microalgae Porphyridium purpureum. Bioresource Technology, 2020, 309, 123362. IF11.39, 1区top

[21] Shaohua Li#, Liang Ji#, Qianwen Shi#, Haizhen Wu, Jianhua Fan*. Advances in the production of bioactive substances from marine unicellular microalgae Porphyridium spp. Bioresource Technology, 2019, 292, 122048. IF11.39, 1区top

[22] Lili Xu, Jianhua Fan*, Quanxi Wang*.Omics application of bio-hydrogen production through green alga Chlamydomonas reinhardtii. Frontiers in Bioengineering and Biotechnology, 2019, 7, 201. IF5.69, 3区

[23] Lili Xu, Huawei Yong, Xiaomeng Tu, Quanxi Wang*, Jianhua Fan*. Physiological and proteomic analysis of Nostoc flagelliforme in response to alkaline pH shift for polysaccharide accumulation.Algal Research, 2019, 39, 101444. IF5.10, 2区

[24] Pengfei Cheng, Chengxu Zhou, et al, Xiaojun Yan*, Jianhua Fan*. Comparative transcriptome analyses of oleaginous Botryococcus braunii race A reveal significant differences in gene expression upon cobalt enrichment. Biotechnology for Biofuels, 2018, 11, 333. IF6.29, 1区top

[25] Lvhong Zheng, Xiaoyan Zhang, Yunpeng Bai*, Jianhua Fan*. Using algae cells to drive cofactor regeneration and asymmetric reduction for the synthesis of chiral chemicals.Algal Research, 2018, 35:432-438. IF5.10, 2区

[26] Jianhua Fan*, Lvhong Zheng, Yunpeng Bai, Shai Saroussi, Arthur Grossman. Flocculation of Chlamydomonas reinhardtii with different phenotypic traits by metal cations and high pH. Frontiers in Plant Science, 2017, 8, 1997. IF5.59, 2区top

[27] Jianhua Fan*, Lvhong Zheng. Acclimation to NaCl and light stress of heterotrophic Chlamydomonas reinhardtii for lipid accumulation. Journal of Bioscience and Bioengineering, 2017, 124(3):302-308. IF2.80, 3区

[28] Conglin Run, Lei Fang, Jianhua Fan*, et al. Stable nuclear transformation of the industrial alga Chlorella pyrenoidosa. Algal Research, 2016, 17:196-201. IF5.10, 2区

[29] Jianhua Fan*, Hui Xu, Yuanguang Li*. Transcriptome-based global analysis of gene expression in response to carbon dioxide deprivation in the green algae Chlorella pyrenoidosa. Algal Research, 2016, 16:12-19. IF5.10, 2区

[30] Jianhua Fan, Kang Ning, Xiaowei Zeng, et al, Jian Xu*, Yuanguang Li*. Genomic foundation of starch-to-lipid switch in oleaginous Chlorella spp. Plant Physiology, 2015, 169(4):2444-2461. IF7.40, 1区top

[31] Jianhua Fan, Hui Xu, Yuanchan Luo, Minxi Wan, Jianke Huang, Weiliang Wang, Yuanguang Li*. Impacts of CO2 concentration on growth, lipid accumulation and carbon concentrating mechanism related genes expression in oleaginous Chlorella. Applied Microbiology and Biotechnology, 2015, 99(5):2451-2462. IF5.00, 3区

[32] Jianhua Fan#, Yanbin Cui#, Minxi Wan, Weiliang Wang, Yuanguang Li*. Lipid accumulation and biosynthesis genes response of the oleaginous Chlorella pyrenoidosa under three nutrition stressors. Biotechnology for Biofuels, 2014, 7, 17. IF6.29, 1区top

[33] Jianhua Fan, Yanbin Cui, Yang Zhou, Minxi Wan, Weiliang Wang, Jingli Xie, Yuanguang Li*. The effect of nutrition pattern alteration on Chlorella pyrenoidosa growth, lipid biosynthesis-related gene transcription. Bioresource Technology, 2014, 164:214-220. IF11.39, 1区top

[34] Jianhua Fan#, Yanbin Cui#, Jianke Huang, Weiliang Wang, Weibo Yin, Zanmin Hu*, Yuanguang Li*. Suppression subtractive hybridization reveals transcript profiling of Chlorella under heterotrophy to photoautotrophy transition. PLoS One, 2012, 7:1-15. IF3.70, 3区

[35] Jianhua Fan, Jianke Huang, Yuanguang Li*, Feifei Han, Jun Wang, Xinwu Li, Weiliang Wang, Shulan Li. Sequential heterotrophy-dilution-photoinduction cultivation for efficient microalgal biomass and lipid production. Bioresource Technology, 2012, 112:206-211. IF11.39, 1区top

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