赵宝祥

山东大学化学与化工学院教授

赵宝祥，男，1959年09月出生，本科毕业于大连理工大学化学工程系，并在该校取得硕士学位。后赴日留学，在名古屋大学取得博士学位。现任山东大学化学与化工学院教授、博导。

人物经历

1978.10-1982.6 大连理工大学化学工程系学习（本科）

1983.9-1986.6 大连理工大学研究生院精细化工系学习（硕士研究生）

1986.7－1993.3 山东省化工研究院工作，工程师

1994.10－1998.3 日本名古屋大学，博士研究生，获得应用化学专业工学博士学位

1998.3－1999.9 山东大学化学院有机化学研究所，副教授

1999.10－2000.7 德国柏林工业大学有机化学研究所博士后研究员

2003.7-2004.6 韩国昌原大学合成化学研究所博士后研究员

2000.7－今山东大学化学与化工学院有机化学研究所，教授

主讲课程

有机化学（化学基地班，双语教学）

有机化学实验,

综合化学实验

有机合成新方法（研究生学位必修课）

合成化学（研究生必修课）

杂环化学（博士研究生）

研究领域

有机合成　药物化学，杂环化学, 化学生物学

主要论著

1. Zhong-Liang Gong, Bao-Xiang Zhao*Available online 26 November 2010.

2. Le Su, HongLing Zhao, ChunHui Sun, BaoXiang Zhao*, Jing Zhao, ShangLi Zhang, Hua Su, and JunYing Miao*, Role of Hmbox1 in Endothelial Differentiation of Bone-Marrow Stromal Cells by a Small Molecule. ACS Chem. Bio. 5 (2010), 1035-1043.

3. Li Wang, ZhiWu Dong,, Bin Huang, BaoXiang Zhao*, Hua Wang, Jing Zhao, HsiangFu Kung, ShangLi Zhang

and JunYing Miao*, Distinct patterns of autophagy evoked by two benzoxazine derivatives in vascular endothelial cells. Autophagy 68 (2010), 1115-1124.

4. Liang-Wen Zheng, Jian Zhu, Bao-Xiang Zhao*, Yao-Hui Huang, Jun Ding, Jun-Ying Miao, Synthesis, Crystal Structure and Biological Evaluation of Novel 2-(5-(Hydroxymethyl)-3-Phenyl-1H-Pyrazol-1-yl)-1-Phenylethanol Derivatives. Eur. J. Med. Chem. 45 (2010) 5792

5. Yong-Sheng Xie, Hong-Ling Zhao, Hua Su, Bao-Xiang Zhao*, Jin-Ting Liu, Ji-Kun Li, Hong-Shui Lv, Bai-Shan Wang, Dong-Soo Shin, Jun-Ying Miao. Synthesis, single-crystal characterization and preliminary biological evaluation of novel ferrocenyl pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives. Eur. J. Med. Chem. 45 (2010) 210-218.

6. ChuanDong Fan, Hua Su, Jing Zhao, BaoXiang Zhao*, ShangLi Zhang, JunYing Miao*, A novel copper complex of salicylaldehyde pyrazole hydrazone induces apoptosis through up-regulating integrin b4 in H322 lung carcinoma cells. Eur. J. Med. Chem. 45, 2010, 1438-1446.

7. Hong-Shui Lv, Bao-Xiang Zhao*, Ji-Kun Li, Yong Xia, Song Lian, Wei-Yong Liu, Zhong-Liang Gong. The synthesis, characterization and optical properties of novel, substituted, pyrazoly 1,3,4-oxadiazole derivatives. Dyes and Pigments 86 (2010) 25-31.

8. Liang-Wen Zheng, Ying Li, Di Ge, Bao-Xiang Zhao*, Ying-Rui Liu, Hong-Shui Lv, Jun Ding, Jun-Ying Miao. Synthesis of novel oxime-containing pyrazole derivatives and discovery of regulators for apoptosis and autophagy in A549 lung cancer cells. Bioorganic & Medicinal Chemistry Letters, Volume 20, Issue 16, 15 August 2010, Pages 4766-4770

9. Zhong-Liang Gong, Liang-Wen Zheng, Bao-Xiang Zhao*, De-Zhong Yang, Hong-Shui Lv, Wei-Yong Liu, Song Lian. The synthesis, x-ray crystal structure and optical properties of novel 1,3,5-triaryl pyrazoline derivatives. Journal of Photochemistry and Photobiology A: Chemistry 209 (2010) 49-55.

10. Wei-Yong Liu, Yong-Sheng Xie, Bao-Xiang Zhao*, Bai-Shan Wang, Hong-Shui Lv, Zhong-Liang Gong, Song Lian, Liang-Wen Zheng, The synthesis, x-ray crystal structure and optical properties of novel 5-aryl-1-arylthiazolyl-3-ferrocenyl-pyrazoline derivatives. Journal of Photochemistry and Photobiology A: Chemistry, 214, 2010, 135-144.

11. Zhong-Liang Gong, Yong-Sheng Xie, Bao-Xiang Zhao*, Hong-Shui Lv, Wei-Yong Liu, Liang-Wen Zheng, Song Lian, The Synthesis, X-ray Crystal Structure and Optical Properties of Novel 5-aryl-3-ferrocenyl-1-pyridazinyl-pyrazoline Derivatives, J Fluoresc, DOI 10.1007/s10895-010-0724-z

12. Wei-Yong Liu, Yong-Sheng Xie, Bao-Xiang Zhao*, Song Lian, Hong-Shui Lv, Zhong-Liang Gong, Dong-Soo Shin, The synthesis, x-ray crystal structure and optical properties of novel 1-ferrocenyl-2-(5-phenyl-1H-1,2,4-triazol-3-ylthio)ethanone derivatives, Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2010, 76 (5), 531-536.

13. Wei-Yong Liu, Yong-Sheng Xie, Bai-Shan Wang and Bao-Xiang Zhao*, 2-[5-(1,3-Benzodioxol-5-yl)-3-ferrocenyl-4,5-dihydro-1H-pyrazol-1-yl]-4-phenyl-1,3-thiazole, Acta Cryst. (2010). E66, m1275

14. Song Lian, Hua Su, Bao-Xiang Zhao*, Wei-Yong Liu, Liang-Wen Zheng, Jun-Ying Miao. Synthesis and discovery of pyrazole-5-carbohydrazide N-glycosides as inducer of autophagy in A549 lung cancer cells. Bioorg. Med. Chem. 17, 2009, 7085-7092.

15 Zheng Liang-Wen, Wu Ling-Ling, Zhao Bao-Xiang*, Dong Wen-Liang, Miao Jun-Ying. Synthesis of novel substituted pyrazole-5-carbohydrazide hydrazone derivatives and discovery of a potent apoptosis inducer in A549 lung cancer cells. Bioorg. Med. Chem. 17, 2009, 1957-1962.

16. Xiao-Ling Ding, Hai-Yan Zhang, Lei Qi, Bao-Xiang Zhao*, Song Lian, Hong-Shui Lv, Jun-Ying Miao. Synthesis of novel pyrazole carboxamide derivatives and discovery of modulators for apoptosis or autophagy in A549 lung cancer cells. Bioorg. Med. Chem. Letters 19, 2009,5325-5328.

17. Wei-Yong Liu, Hai-Ying Li, Bao-Xiang Zhao*, Dong-Soo Shin, Song Lian, Jun-Ying Miao.Synthesis of novel ribavirin hydrazone derivatives and anti-proliferative activity against A549 lung cancer cells. Carbohydrate Research 344 (2009) 1270–1275.

18. Yong-Sheng Xie, Bao-Xiang Zhao*, Hong-Shui Lv, Ji-Kun Li, Bai-Shan Wang, Dong-Soo Shin. Synthesis and single-crystal characterization of novel 2-ferrocenyl-4H-pyrazolo[5,1-c][1,4]oxazin-4-one derivatives. Journal of Molecular Structure 930 (2009) 83–87.

19. Jin-Hua Zhang, Hua Zuo, Yong-Sheng Xie and Bao-Xiang Zhao*. 2-(4-Chlorophenyl)-5-(3,4-dimethoxyphenethyl)-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one. Acta Cryst. (2009). E65, o1457.

20. Zheng Tang, Xiao-Liang Ding, Wen-Liang Dong and Bao-Xiang Zhao*. 1-[(6-Chloro-3-pyridyl)methyl]-N-(4-ethoxyphenyl)-3-phenyl-1H-pyrazole-5-carboxamide. Acta Cryst. (2009). E65, o865–o866.

21. Zheng Tang, Xiao-Ling Ding, Yong-Sheng Xie andBao-Xiang Zhao*. 1-(4-tert-Butylbenzyl)-3-phenyl-1H-pyrazole-5-carboxylic Acid. Acta Cryst. (2009). E65, o1273.

22. Jin-Hua Zhang, Chuan-Dong Fan,Bao-Xiang Zhao*, Dong-Soo Shin, Wen-Liang Dong, Yong-Sheng Xie, Jun-Ying Miao.Synthesis and preliminary biological evaluation of novel pyrazolo[1,5-a]pyrazin-4(5H)-one derivatives as potential agents against A549 lung cancer cells. Bioorg. Med. Chem. 16，2008，10165.

23. Bao-Xiang Zhao*, Lu Zhang, Xing-Shang Zhu, Mao-Sheng Wan, Jing Zhao, Yun Zhang, Shang-Li Zhang, Jun-Ying Miao. Synthesis and discovery of a novel pyrazole derivative as an inhibitor of apoptosis through modulating integrin β4, ROS and p53 levels in vascular endothelial cells. Bioorg. Med. Chem. 16，2008，5171.

24. Wen-Liang Dong, Bao-Xiang Zhao*, Fang Wei, Hua Zuo, Dong-Soo Shin. Unexpected Novel Rearrangement Reaction; Synthesis of Benzo-Medium Ring Anhydride. Synthetic Communications 2008, 38, 1224.

25. Xie Yong-Sheng, Pan Xiao-Hong, Zhao Bao-Xiang*, Liu Jin-Ting, Shin Dong-Soo, Zhang Jin-Hua, Zheng Liang-Wen, Zhao Jing, Miao Jun-Ying. Synthesis, structure characterization and preliminary biological evaluation of novel 5-alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives. J. Organometallic Chemistry 693，2008, 1367.

26. Yong Xia, Chuan-Dong Fan, Bao-Xiang Zhao*, Jing Zhao, Dong-Soo Shin, Jun-Ying Miao. Synthesis and structure-activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole-5-carbohydrazide hydrazone derivatives as potential agents against A549 lung cancer cells. Eur. J. Med. Chem. 43, 2008, 2347-2353.

27. Xiao-Hong Pan, Xia Liu, Bao-Xiang Zhao*, Yong-Sheng Xie, Dong-Soo Shin, Shang-Li Zhang, Jing Zhao, Jun-Ying Miao. 5-Alkyl-2-ferrocenyl-6,7-dihydropyrazolo[1,5-a]pyrazin-4(5H)-one derivatives inhibit growth of lung cancer A549 cell by inducing apoptosis. Bioorg. Med. Chem. 16, 2008, 9093.

28. Chuan-Dong Fan, Bao-Xiang Zhao*, Fang Wei, Gai-Hua Zhang, Wen-Liang Dong, Jun-Ying Miao. Synthesis and discovery of autophagy inducers for A549 and H460 lung cancer cells, novel 1-(2′-hydroxy-3′-aroxypropyl)-3-aryl-1H-pyrazole-5-carbohydrazide derivatives. Bioorg. Med. Chem. Letters 18, 2008, 3860.

29. Wen-Liang Dong, Yan-Qing Ge and Bao-Xiang Zhao*. Ethyl 5-(ethoxycarbonyl)-3-(4-methoxyphenyl)-1H-pyrazole-1-acetate. Acta Cryst. (2008). E64, o64.

30. Jin-Hua Zhang, Wen-Liang Dong, Yan-Qing Ge and Bao-Xiang Zhao*. 1-(2-Hydroxy-5-methoxyphenyl)ethan-1-one-N-[(E )-1-(2-hydroxy-5-methoxyphenyl)ethylidene]hydrazone. Acta Cryst. (2008). E64, o166.

31. Yong Xia, Zhi-Wu Dong, Bao-Xiang Zhao,* Xiao Ge, Ning Meng, Dong-Soo Shin, Jun-Ying Miao. Synthesis and structure–activity relationships of novel 1-arylmethyl-3-aryl-1H-pyrazole -5-carbohydrazide derivatives as potential agents against A549 lung cancer cells.Bioorg. Med. Chem. 2007, 15, 6893-6899.

32. Qiuxia He, Xingshang Zhu, Mei Shi, Baoxiang Zhao*, Jing Zhao, Shangli Zhang and Junying Miao. Novel morpholin-3-one derivatives induced apoptosis and elevated the level of P53 and Fas in A549 lung cancer cells. Bioorg. Med. Chem. 15 (2007) 3889–3895.

33. Weiwei Wang, Xia Liu, Yun Zhang, Jing Zhao, Baoxiang Zhao*, Shangli Zhang, Junying Miao*. Both senescence and apoptosis induced by deprivation of growth factors were inhibited by a novel butyrolactone derivative through depressing integrinβ4 in vascular endothelial cells. Endothelium. 2007 14(6):325-332.

34. Zhao J, Zhao BX*, Wang WW, Huang B, Zhang SL, Miao JY Phosphatidylcholine-specific phospholipase C and ROS were involved in chicken blastodisc differentiation to vascular endothelial cells. Journal of Cellular Biochemistry 2007,102(2):421-428.

35. Le Su, BaoXiang Zhao, Xin Lv, Jing Zhao, ShangLi Zhang and JunYing Miao. Safrole oxide is a useful tool for investigating the effect of apoptosis in vascular endothelial cells on neural stem cell survival and differentiation in vitro. Bioorg Med Chem Lett. 2007, 17: 3167-3171.

36. Le Su, BaoXiang Zhao*, Xin Lv, Nan Wang, Jing Zhao, ShangLi Zhang and JunYing Miao，Safrole oxide induces neuronal apoptosis through inhibition of integrin β4/SOD activity and elevation of ROS/NADPH oxidase activity. Life Sciences, 2007, 80, 999-1006.

37. Weiwei Wang, Xia Liu, Jing Zhao,Baoxiang Zhao*, Shangli Zhang and Junying Miao. A novel butyrolactone derivative inhibited apoptosis and depressed integrin ?4 expression in vascular endothelial cells. Bioorg. Med. Chem. Letters 17 (2007) 482–485.

38. DING, Xiao-Ling; MENG Ning; XIA, Yong; WANG, Li-Juan; ZHANG, Xiao-Feng; ZHAO, Bao-Xiang; MIAO Jun-Ying. Synthesis and bioactivity evaluation of ethyl 1-arylmethyl-3-aryl-1H-pyrazole-5-carboxylate Derivatives. Chin. J. Org. Chem. 2007, 27, 1542-1546. (in Chinese).

39. ZHAO Bao-xiang, SCHAUDT Marco and BLECHERT Siegfried. Syntheses of Macrocyclic Amides from L-Amino Acid Esters by RCM. CHEM. RES. CHINESE U. 2007, 23 ( 1 ) , 22-30.

40. DONG Wen-Liang, ZHAO Bao-Xiang, SHIN Doo-Soo, WEI Fang, YAO Wei-Jian, XIA Yong, GE Yan-Qing Synthesis and photochromic properties of 2-(1-benzyl-3-methyl-2-indolylmethylene)-3-isopropylidenesuccinic anhydride. Chin. J. Org. Chem. 2007, 27 (7), 847. (in Chinese).

41 Fang Wei, Bao-Xiang Zhao, Wen-Liang Dong, Zuo Hua, Dong-Soo Shin, Da-Wei Wang, Yong Xia, Yan-Qing Ge. Microwave-assisted Rapid and Straightforward Synthesis of Novel 6-(Aroxymethyl)-2-aryl-6,7- dihydropyrazolo[5,1-c][1,4]oxazin-4-one Derivatives. Synthetic Communications 2007, 37, 4415-4424.

42. Wen-Liang Dong, Wei-Jian Yao, Fang Wei and Bao-Xiang Zhao. (3Z,4Z)-3,4-Bis(1,3-benzodioxol-5-ylmethylene)-tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o2776–o2777.

43. Wen-Liang Dong, Jin-Hua Zhang, Liang-Wen Zheng and Bao-Xiang Zhao. (3E,4Z)-3-[(1,3-Benzodioxol-5-yl)methylene]-4-(2-pentylidene)tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o3040.

44. Wen-Liang Dong, Jin-Hua Zhang, Liang-Wen Zheng, Fang Wei and Bao-Xiang Zhao 3-[(1,3-Benzodioxol-6-yl)methylene]-4-(pentan-3-ylidene)tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o3066.

45. Yong Xia, Xiao-Ling Ding, Yan-Qing Ge, Lian-Dong Liu and Bao-Xiang Zhao. Ethyl 1-[(6-chloropyridin-3-yl)methyl]-3-phenyl-1H-pyrazole-5-carboxylate. Acta Cryst. (2007). E63, o394–o395.

46. Yong Xia, Wen-Liang Dong, Yang-Qing Ge, Fang Wei and Bao-Xiang Zhao. Ethyl 1-benzyl-3-(4-chlorophenyl)-1Hpyrazole-5-carboxylate. Acta Cryst. (2007). E63, o1613–o1614.

47 Yong Xia, Wen-Liang Dong, Xiao-Ling Ding and Bao-Xiang Zhao. Ethyl 1-(4-tert-butylbenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylate. Acta Cryst. (2007). E63, o3257.

48. Yong Xia, Wen-Liang Dong, Xiao-Ling Ding and Bao-Xiang Zhao. Ethyl 1-benzyl-3-phenyl-1H-pyrazole-5-carboxylate. Acta Cryst. (2007). E63, o3298.

49 Yong-Sheng Xie, Wen-Liang Dong, Liang-Wen Zheng, Jin-Hua Zhang and Bao-Xiang Zhao. Ethyl 1-(2-bromoethyl)-3-ferrocenyl-1Hpyrazole-5-carboxylate. Acta Cryst. (2007). E63, m978–m979.

50. Xiao-Ling Ding, Wen-Liang Dong, Yong Xiaa and Bao-Xiang Zhao. 1-(4-tert-Butylbenzyl)-3-(4-chlorophenyl)-1H-pyrazole-5-carboxylic acid. Acta Cryst. (2007). E63, o3125.

51. Zheng Tang, Xiao-Ling Ding, Wen-Liang Dong and Bao-Xiang Zhao. 1-(6-Chloropyridin-3-ylmethyl)-3-phenyl-1H-pyrazole-5-carboxylic acid. Acta Cryst. (2007). E63, o3348.

52. Yan-Qing Ge, Yong Xia, Fang Wei, Wen-Liang Dong and Bao-Xiang Zhao. N-Benzyl-5-phenyl-1H-pyrazole-3-carboxamide. Acta Cryst. (2007). E63, o1186–o1187.

53. Yan-Qing Ge, Yong Xia, Wen-Liang Dong, Fang Wei and Bao-Xiang Zhao. 2-{5-[N-(4-tert-Butylbenzyl)carbamoyl]-3-phenyl-1H-pyrazol-1-yl}acetic acid. Acta Cryst. (2007) E63, o1287–o1288.

54. Yan-Qing Ge, Wen-Liang Dong, Yong Xia, Fang Wei and Bao-Xiang Zhao. Ethyl 3-(2-hydroxy-5-methylphenyl)-1Hpyrazole-5-carboxylate. Acta Cryst. (2007). E63, o1313–o1314.

55. Liang-Wen Zheng, Wen-Liang Dong, Jin-Hua Zhang and Bao-Xiang Zhao. (3E,4E)-3-(1,3-Benzodioxol-5-ylmethylene)-4-(1-phenylethylidene)-tetrahydrofuran-2,5-dione. Acta Cryst. (2007). E63, o3567.

56. Zheng Tang, Xiao-Ling Ding, Wen-Liang Dong and Bao-Xiang Zhao. 1-Benzyl-3-phenyl-1H-pyrazole-5-carboxylic acid. Acta Cryst. (2007). E63, o3473.

57. Fang Wei, Bao-Xiang Zhao, Bin Huang, Lu Zhang, Chun-Hui Sun, Wen-Liang Dong, Dong-Soo Shin, Jun-Ying Miao. Design, synthesis and preliminary biological evaluation of novel ethyl 1-(2’-hydroxy-3’-aroxypropyl)-3-aryl-1H-pyrazole-5-carboxylate. Bioorg. Med. Chem. Letters 2006, 16, 6342.

58. Pei-Fu Jiao, Bao-Xiang Zhao, Wei-Wei Wang, Qiu-Xia He, Mao-Sheng Wan, Dong-Soo Shin, Jun-Ying Miao. Design, synthesis and preliminary biological evaluation of 2,3-dihydro-3-hydroxymethyl-1,4-benzoxazine derivatives. Bioorg. Med. Chem. Letters 2006, 16, 2862.

59. ZHAO, Bao-Xiang; SCHAUDT, Marco; BLECHERT, Siegfried. Design and Synthesis of Potential Macrocyclic Zinc Metalloprotease Inhibitors. Chin. J. Chem., 2006, 24, 1080-1085.

60. Wan Mao-Sheng, Zhao Bao-Xiang, He Qiu-Xia, Jiao Pei-Fu, Wang Da-Wei, Miao Jun-Ying. Synthesis and bioactivity evaluation of ethyl 6-amino-2-substituted-1H-indole-3-carboxylates and their derivatives. Chin. J. Org. Chem. 2006, 26 (9), 1248-1253. (in Chinese).

61. Nan Wang, Xin Lv, Le Su, BaoXiang Zhao, ShangLi Zhang and JunYing Miao, D609 blocks cell survival and induces apoptosis in neural stem cells. Bioorg. Med. Chem. Letters 16 (2006) 4780–4783.

62. Chuandong Fan, Weiwei Wang, Baoxiang Zhao, Shangli Zhanga, and Junying Miao. Chloroquine inhibits cell growth and induces cell death in A549 lung cancer cells. Bioorg. Med. Chem. 2006, 14, 3218-3222.

63. Le Su, Jing Zhao, Bao Xiang Zhao, Jun Ying Miao, De Ling Yin, Shang Li Zhang, Safrole oxide induced human umbilical vein vascular endothelial cell differentiation into neuron-like cells by depressing the reactive oxygen species level at the low concentration. BBA-MOL CELL RES 2006, 1763, 247-253.

64. Du AY, Zhao BX, Yin DL, Zhang SL, Miao JY. Safrole Oxide Induces Apoptosis by Up-regulating Fas and FasL instead of Integrin β4 in A549 Human Lung Cancer Cells. Bioorg. Med. Chem. 2006, 14, 2438-3445.

65. Wei Tan, Bao-Xiang Zhao, Lei Sha, Pei-Fu Jiao, Mao-Sheng Wan, Lei Su, and Dong-Soo Shin MICROWAVE-ASSISTED RING OPENING OF EPOXIDES IN SOLVENT FREE CONDITIONS. Synthetic Communications 2006, 36 (10), 1353-1359.

66. TAN, Wei; ZHAO, Bao-Xiang; SHI, Mei; SHA, Lei; MIAO, Jun-Ying; SHIN, Dong-Soo Facile Synthesis and Evaluation of Cell A549 Growth Inhibitory Activity of 4-Aryl-6-aryloxymethylmorpholin-3-one Derivatives. Chin. J. Chem., 2006, 24, 396-400.

67. SHA, Lei; ZHAO, Bao-Xiang; FAN, Chuan-Dong; TAN, Wei; LI, Xun; MIAO, Jun-Ying. Synthesis and Primary Evaluation of Lung Cancer Cell Growth Inhibitory Activity of Novel 3-Arylmethyl-5-aroxymethylbutyrolactones. Chin. J. Org. Chem. 2006, 26 (4), 537-541.

68. Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang. Suppressing the Akt/NOS signal pathway and activating Fas protein in bFGF stimulated angiogenesis and VEC growth by Safrole oxide. The international journal of biochemistry and cell biology. 2006, 38，1603-1613.

69. AiYing Du, BaoXiang Zhao, DeLing Yin, ShangLi Zhang and JunYing Miao, Safrole oxide induces apoptosis by activating caspase-3, -8, and -9 in A549 human lung cancer cells. Bioorg. Med. Chem. Letters 16 (2006) 81–83

70. Jing Zhao, Junying Miao, Baoxiang Zhao, Shangli Zhang Upregulating of Fas, integrin b4 and P53 and depressing of PC-PLC activity and ROS level in VEC apoptosis by safrole oxide. FEBS Letters 2005, 579, 5809–5813

71. Ai-Ying Du, Bao-Xiang Zhao, De-Ling Yin,c Shang-Li Zhanga and Jun-Ying Miao Discovery of a novel small molecule, 1-ethoxy-3-(3,4-methylenedioxyphenyl)-2-propanol, that induces apoptosis in A549 human lungcancer cells. Bioorg. Med. Chem. 2005, 13, 4176-4183.

72. Jing Zhao, Bao-Xiang Zhao, Junying Miao, Shangli Zhang, Deling Yin. Safrole oxide inhibits angiogenesis by inducing apoptosis. Vascular Pharmacology，2005，43, 69-74.

73. TAN, Wei; ZHAO, Bao-Xiang; SHA, Lei; JIAO, Pei-Fu; WAN, Mao-Sheng; SU, Lei Alumina catalyzed synthesis of β-aminoalcohols from epoxides and aromatic amines. Chin. J. Org. Chem. 2005, 25, 1011-1014. (in Chinese).

74. Zuo Hua, Zhao Bao-Xiang, Wang Da-Wei, Progress in antidiabetic drugs. China New Drugs 2005, 14(6) 672-678. (in Chinese)

科研项目

1. 教育部留学回国人员科研启动基金，负责人（1999－）

2. 山东大学杰出青年科研基金，负责人（1999－）

3. 山东大学跨学科预研基金，负责人（2002－）

4. 山东省自然科学基金重点项目（第二负责人）（2003－2005）

5. 教育部重点项目，负责人（2004－2006）

6. 山东省自然科学基金项目，负责人（2006－2008）

7.山东省科技发展计划科研项目，负责人（2008-2010）

8. 山东省自然科学基金重点项目，负责人（2008.12-2011.12）

9. 国家自然科学基金项目（交叉学科化学生物学，主要参加者）（2009-2011）

10. 国家973前期项目（排名第二）（2009-2011）