郭卫

北京大学人民医院骨肿瘤科主任医师

郭卫，主任医师，北京大学二级教授，博士生导师。现任北京大学人民医院骨肿瘤科主任、骨肿瘤研究室主任，北京大学人民医院骨科教研室主任，中国医师学会骨科分会骨肿瘤专业委员会主任委员，中国抗癌协会骨肿瘤和骨转移瘤专业委员会主任委员。亚太地区骨肿瘤学会（APMSTS）前任主席，国际保肢学会（ISOLS）前任主席，中华医学会骨科学会骨肿瘤学组组长（2005-2017）。

个人经历

1979-1984　就读青岛医学院医疗系，获医学学士学位

1984-1986　青岛医学院附属医院骨科住院医生

1986-1989　就读中山医科大学，获骨科学硕士学位

1989-1990　青岛医学院附属医院骨科主治医生

1990-1993　就读北京医科大学，获骨科学博士学位

1993-1995　北京医科大学人民医院骨科主治医生，副主任医师，副教授

1996.01-1998.07　美国纽约Memorial Sloan-Kettering Cancer Center 骨肿瘤科进修

1998-2002　北京大学人民医院骨肿瘤科副主任，骨病骨肿瘤研究室主任，主任医师，教授

2002-至今　北京大学人民医院骨肿瘤科主任，骨肿瘤研究室主任，北京大学人民医院骨科教研室主任，主任医师，二级教授，博士生导师

社会兼职

中国医师学会骨科分会骨肿瘤专业委员会主任委员

中国抗癌协会骨肿瘤和骨转移瘤专业委员会主任委员

国际骶骨骨盆肿瘤研究协作组（Sacral and Pelvic Tumor Study Group）主席

SICOT中国部骨肿瘤专业委员会主任委员

中国抗癌协会肉瘤专业委员会副主任委员

海峡两岸医药卫生交流协会骨科专业委员会副主任委员

中国医疗保健促进会软组织肿瘤分会副主任委员

中国医师学会骨科分会3D打印专业委员会副主任委员

擅长领域

四肢骨与软组织恶性肿瘤的保肢治疗，骶骨肿瘤的手术治疗，骨盆肿瘤的手术治疗，脊柱肿瘤的外科治疗，恶性骨与软组织恶性肿瘤的化疗。

出诊时间

周一、周二上午。

出版图书

学术杂志编委

美国J Bone and Joint Surg（JBJS）副主编

Chinese Medical Journal（中华医学杂志英文版）编委

中华骨科杂志编委

中华外科杂志编委

Journal of Orthopaedic Science（日本骨科杂志）编委

中国脊柱脊髓杂志编委

中国肿瘤临床杂志编委

中华骨与关节外科副主编

中国矫形外科杂志副主编

国际骨科学杂志副主编

临床骨科杂志编委

中华关节外科杂志常务编委

中国骨与关节外科杂志常务编委

肿瘤基础与临床研究杂志编委

生物骨科材料与临床研究编委

中国骨科临床与基础研究杂志常务编委

中国肩肘外科杂志副主编

中国骨伤杂志编委

《骨科》杂志副主编

学术著作编委

骨与软组织肿瘤诊断与治疗.主译,2006,天津科技翻译出版公司.

骨盆肿瘤外科学.主编,2009, 北京大学出版社.

骨与软组织肿瘤学.副主编,2008,人民卫生出版社.

膝关节外科学.副主编,2011,人民卫生出版社.

中华骨科学（骨肿瘤分册主编）,2010,人民卫生出版社.

脊柱肿瘤学.主译,2010,北京大学出版社.

骨科病理学图谱.主译,2011,北京大学出版社.

肿瘤型人工关节置换手术.主编,2011,人民军医出版社.

八年制外科学教材.第二版,骨肿瘤章编写,2010,人民卫生出版社.

骨转移性肿瘤外科学.主编,2012,人民卫生出版社.

骨盆肿瘤外科学（第二版）.主编,2015,北京大学出版社.

八年制外科学教材.第三版,骨肿瘤章编写,2015,人民卫生出版社.

骨科学（研究生教材）.副主编,骨肿瘤篇编写,2015,人民卫生出版社.

骨科手术学（第四版）骨与软组织肿瘤篇.主编,2015,人民卫生出版社.

《Surgery of the Pelvic and Sacral Tumor》.2020,主编,Springer.

获奖及荣誉称号

1. 主持“原发恶性骨肿瘤的规范化切除及功能重建的系列研究” 获国家科技进步二等奖（2014）

2. 主持“原发恶性骨肿瘤的规范化切除及功能重建的系列研究” 获中华医学科技进步一等奖（2013）

3. 主持“骨盆环肿瘤的切除及功能重建” 获北京市科技进步二等奖（2011）

4. 主持“原发恶性骨肿瘤的发病机制研究” 获中华医学科技成果二等奖（2003）

5. 主持“骨肉瘤化疗的临床及基础研究” 获北京市科技进步三等奖（2005）

6. 主持“骨盆环肿瘤的切除及功能重建” 获中华医学会科技成果三等奖（2009）

7. 主持“骨盆环肿瘤的切除及功能重建”获第十二届吴杨奖

8. 主持“原发恶性骨肿瘤的病因学研究”获北京市科技进步三等奖（2003）

9. 主持“原发恶性骨肿瘤的分子生物学研究”获北京市科技进步三等奖（2001）

10. 参与“骨巨细胞瘤细胞生物学，细胞遗传学及免疫学研究”获教育部科技进步二等奖（1999）

11. 京城好医生（2015）

12. 金柳叶刀奖（2017）

13.2023年5月，被授予第三届全国创新争先奖状。

发表论文

以第一作者或通讯作者发表论文400余篇，其中SCI论文150余篇。主要如下：

姬涛,杨荣利,杜志业,唐顺,汤小东,郭卫. 超半盆截肢治疗六例巨大骨盆骶骨肿瘤的经验总结. 中华外科杂志,2018,56(2):157-160.

Qu H, Guo W,et al.Functional results of arthrodesis versus arthroplasty of radiocarpal joints reconstructed by proximal fibula autograft following resection of a Campanacci grade III giant cell tumour of the distal radius. Journal of Hand Surgery. European Volume.（accepted）

Xiaodong Tang, Rongli Yang, Huayi Qu,et al. Factors Associated With Spinopelvic Fixation Mechanical Failure After Total Sacrectomy. Spine, 43,2018

Xie L, Guo W, Yang Y, Ji T, Xu J. More severe toxicity of genetic polymorphisms on MTHFR activity in osteosarcoma patients treated with high-dose methotrexate.Oncotarget. 2018; 9(14):11465-11476.

Chen Z,Yang Y,Guo W,Yang R,Tang X,Yan T,Ji T,Xie L,Xu J,Wang J.Therapeutic benefits of neoadjuvant and post-operative denosumab on sacral GCT: a retrospective cohort study of 30 cases. J BUON.2018 Mar-Apr;23(2):453-459.

杨毅,梁海杰,郭卫,姬涛. Denosumab联合手术治疗动脉瘤样骨囊肿效果和安全性的初步观察. 中华外科杂志,2018,56(2):153-156.

Zheng B, Ren T，Huang Y, Guo W. Apatinib inhibits migration and invasion as well as PD-L1 expression in osteosarcoma by targeting STAT3. Biochem Biophys Res Commun.2018 Jan 8;495(2):1695-1701.

Zheng B, Ren T, Huang Y, Sun K, Wang S, Bao X, Liu K, Guo W. PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse. J Hematol Oncol. 2018 Feb 6;11(1):16.

杨毅;郭卫;杨荣利;汤小东;燕太强;姬涛;梁海杰;陈忠岩.地诺单抗联合手术治疗桡骨骨巨细胞瘤-外科降级及预后.骨科.2018.01.

尉然,郭卫,杨荣利,汤小东,燕太强,李大森,杨毅,姬涛. 钢板-假体复合体重建长节段受累的肱骨上段肿瘤切除后骨缺损. 中国骨与关节杂志.2018,01:25-32.

杨毅,贾俊秀,郭卫,杨荣利,汤小东,燕太强,王军,陈忠岩. 保留踝关节的自体瘤骨灭活再植重建胫骨下段骨肉瘤切除后骨缺损二例报道并文献复习. 中国骨与关节杂志.2018,02:132-137.

Xie L, Guo W,Wang Y,Yan T,Ji T,Xu J. Apatinib for advanced sarcoma: Results from multiple institutions’off-label use in China. BMC Cancer. 2018 Apr 6;18(1):396.

Zhang H,Yang K,Ren T,Huang Y,Tang X,Guo W. miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3. Cell Death Dis.2018 Jun 7;9(6):680.

Zhang F, Yan T, Guo W, Sun K, Wang S, Bao X, Liu K, Zheng B, Zhang H, Ren T. Novel oncogene COPS3 interacts with Beclin1 and Raf-1 to regulate metastasis ofosteosarcoma through autophagy. J Exp Clin Cancer Res. 2018 Jul 3;37(1):135.

Haijie Liang, Wei Guo, Rongli Yang, Xiaodong Tang, Taiqiang Yan. Comparison between uncemented and cemented fixation for the tibial component in distal femoral replacement: a clinical and radiological study. Int Orthop. 2018 Sep;42(9):2249-2261.

Liang Haijie, Li Dasen, Ji Tao, Yang Yi, Tang Xiaodong, Guo Wei. Implant Survival and Complication Profiles of Endoprostheses for Treating Tumor Around the Knee in Adults: A Systematic Review of the Literature Over the Past 30 Years. J Arthroplasty. (2018) 33(4):1275-1287.

Liang Haijie, Guo Wei, Yang Rongli, Tang Xiaodong, Yan Taiqiang, Ji Tao, Yang Yi, Li Dasen, Xie Lu, Xu Jie. Radiological characteristics and predisposing factors of venous tumor thrombus in pelvic osteosarcoma: a mono-institutional retrospective study of 115 cases. Cancer Med. 2018 Oct;7(10):4903-4913.

Zhang Y, Guo W, Tang X, Yang R, Yan T, Dong S, Wang S, Zaphiros N. CanAortic Balloon OcclusionReduce Blood Loss During Resection of Sacral Tumors That Extend Into the Lower Lumber Spine? Clin Orthop Relat Res. 2018 Mar;476(3):490-498.

Zhang Y,Guo W,Tang X,Yang R,Ji T,Yang Y,Wang Y,Wei R. Enblocresectionofpelvicsarcomaswithsacral invasion. Bone Joint J.2018 Jun 1;100-B(6):798-805.

Zhang Y,Tang X,Ji T,Yan T, Yang R,Yang Y, Wei R, Liang H,Guo W. Is a Modular Pedicle-hemipelvic Endoprosthesis Durable at Short Term in Patients Undergoing Enneking Type I + II Tumor Resections With or Without Sacroiliac Involvement? Clin Orthop Relat Res (2018) 0:1-11.

郭卫,尉然. 中国骶骨肿瘤外科治疗的进步. 中华骨与关节外科杂志,2018, 11(4)241-251.

郭卫,牛晓辉,肖建如等.多发性骨髓瘤骨病外科治疗循证医学指南.中华骨与关节外科杂志,2018, 11(4)252-259.

郭卫,王臻,郭征等. 尤文肉瘤肿瘤家族（ESFT）临床循证诊疗指南. 中华骨与关节外科杂志,2018, 11(4)261-275.

郭卫,李建民,沈靖南等. 骨巨细胞瘤临床循证诊疗指南. 中华骨与关节外科杂志,2018, 11(4)276-287.

郭卫,牛晓辉,肖建如等. 骨肉瘤临床循证诊疗指南. 中华骨与关节外科杂志,2018, 11(4)288-301.

郭卫,邵增务,张伟滨等. 软骨肉瘤临床循证诊疗指南. 中华骨与关节外科杂志,2018, 11(4)302-311.

Jie Xu, Lu Xie, and Wei Guo. Neuadjuvant Chemotherapy Fellowed by Delayed Surgery: Is it Necessary for All Patients With Nonmetastatic High-Grade Pelvic Osteosarcoma? Clin Orthop Relat Res (2018) 0:1-10.

Li D, Xie L, Guo W, Tang X, Ji T, Yang R. Extra-articular resection is a limb-salvage option for sarcoma involving the hip joint. Int Orthop. 2018 Mar;42(3):695-703.

孙馨,郭卫,杨荣利,汤小东,唐顺,李大森. 单中心高度恶性软组织肉瘤的诊疗经验.中国癌症杂志,2018,28(3):210-215.

Yu Han; Wei Guo; Tingting Ren; Yi Huang; Shidong Wang; Kuisheng Liu; Bingxin Zheng; Kang Yang; Hongliang Zhang; Xin Liang.Tumor-associated macrophages promote lung metastasis and induce epithelial-mesenchymal transition in osteosarcoma by activating the COX-2/STAT3 axis. cancer letters

Bingxin Zheng; Tingting Ren; Wei Guo; Yi Huang；Kunkun Sun；Shidong Wang; Xin Bao；Kuisheng Liu; PD-1 axis expression in musculoskeletal tumors and antitumor effect of nivolumab in osteosarcoma model of humanized mouse. Journal of Hematology & Oncology,2018. 11(16):1-13.

Bingxin Zheng; Wei Guo; Tingting Ren; Yi Huang.Apatinib inhibits migration and invasion as well as PD-L1 expression in osteosarcoma by targeting STAT3. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS.2018.495(2):1695-1701.

臧杰,郭卫,汤小东,曲华毅,李大森. 人工韧带在耻骨肿瘤切除后重建下腹壁缺损中的应用.北京大学学报（医学版）.2018,50:111.

Jie Xu，Lu Xie, Wei Guo.Combination of gemcitabine and docetaxel: a regimen overestimated in refractory metastatic osteosarcoma? BMC Cancer. 2018 Oct 16;18(1):987.

杨毅,郭卫. 分离手术结合三维适型调强放疗治疗骶骨复发难治肿瘤的回顾性研究. 中华骨与关节外科杂志,2018,07.

杨毅,郭卫. 恶性骨肿瘤保肢治疗中灭活再植技术的操作流程和常见问题. 骨科,2018,9(3).

Hongliang Zhang ，Xiaodong Tang，Kang Yang，Tingting Ren， Yi Huang .miR-16-5p inhibits chordoma cell proliferation, invasion and metastasis by targeting Smad3. Cell Death & Disease.2018,9(680):1-13.

黄思议,郭卫,姬涛. 全骶骨切除术后重建的方法的发展及现状.中国修复重建外科杂志.2018,32(5):513-518.

Zhiye Du,Wei Guo, Shun Tang, Rongli Yang, Xiaodong Tang, Tao Ji.Use of an Artificial Ligament Decreases Hip Dislocation and Improves Limb Function After Total Femoral Prosthetic Replacement Following Femoral Tumor Resection. J ARTHROPLASTY.2018，33(5)：1507-1514.

Tang B, Ji T, Guo W, Tang X, Jin L, Dong S, Xie L.Which is the better timing between embolization and surgery for hypervascular spinal tumors, the same day or the next day?: A retrospective comparative study. Medicine (Baltimore). 2018 Jun;97(23):e10912.

王冀川,郭卫,杨毅,汤小东,燕太强,杨荣利. 股骨远端肿瘤型膝关节假体中长期假体存留及失败类型分析. 中国骨与关节杂志,2018,7(7), 535-540.

Z.Q, Zhao, T.Q. Yan, W. Guo, et al. Surgical treatment of primary malignant tumors of the distal tibia. Bone Joint J.2018, Dec;100-B(12) :1633-1639.

郭卫. 中国骨科肿瘤专业的发展与展望.中华外科杂志,2019,(57)1:23-28.

郭卫. 肿瘤型人工关节的发展与临床应用. 中国骨与关节杂志,2019,8(5):321-327.

谢璐,许婕,李原等. 骨来源恶性肿瘤临床疗效的评估. 中国肿瘤临床2019年,46(4)186-191.

郭卫. 少年儿童膝关节恶性肿瘤切除后的重建方法. 中华解剖与临床杂志,2019,24(3)197-202.

ZhaoZhiqing, Yan Taiqiang, Wei Guo，Rongli Yang, Xiaodong Tang, Wei Wang. Surgical options and reconstruction strategies for primary bone tumors of distal tibia: A systematic review of complications and functional outcome. Journal of Bone Oncology, 2019 (14).

张帆,燕太强,郭卫. Rasfonin 抑制骨肉瘤细胞143B的增殖和迁移.北京大学学报(医学版),2019,51(2):234-238.

燕太强,董森,郭卫,等.全肘关节置换术在严重类肿瘤病变治疗中的初步临床应用.中华骨科杂志,2019,39(2): 90-97.

Zhao Zhiqing, Yan Taiqiang, Tang Xiaodong, Guo Wei, Yang Rongli,Tang Shun. Novel “double-strut” fibula ankle arthrodesis for large tumor-related bone defect of distal tibia. BMC Musculoskeletal Disorders, 2019, 20(1):367.

Y an T, zhao Z, Tang X, Guo W, Yang R, Tang S, Dong S. Improving functional outcome and quality of life for patients with metastatic lesion of acetabulum undergoing cement augumentation. Medicine, 2019, 98(36)

Qu H, Li D, Tang S, Zang J, Wang Y, Guo W. Pelvic reconstruction following resection of tumour involving the whole ilium and acetabulum. J Bone Oncol. 2019 Mar 27;16:100234.

Qu H, Guo W, Li D, Yang Y, Wei R, Xu J. Functional results of wrist arthrodesis versus arthroplasty with proximal fibula following giant cell tumour excision of the distal radius. J Hand Surg Eur Vol. 2019 May;44(4):394-401.

Zang J, Zuo D, Shogren KL, Gustafson CT, Zhou Z, Thompson MA, Guo R, Prakash YS, Lu L, Guo W et al: STIM1 expression is associated with osteosarcoma cell survival. Chinese journal of cancer research = Chung-kuo yen cheng yen chiu 2019, 31(1):203-211.

Zang J, Guo W, Yang Y, Wei R: Surgical treatment of giant benign sacral neurogenic tumors using the posterior-only approach. Clin Neurol Neurosurg 2019, 185:105483.

Ji T, Guo W. The evolution of pelvic endoprosthetic reconstruction after tumor resection. Ann Joint 2019;4:29 (Review)

Ji T, Yang Y, Li D, Tang X, Guo W. Limb salvage using non-hinged endoprosthesis and staged distraction osteogenesis for children with distal femoral malignant tumors. Ortho Surg 2019 Sep 5 [Epub ahead of print]

Siyi Huang, Tao Ji, Wei Guo, Biomechanical comparison of a 3D-printed sacrum prosthesis versus rod-screw systems for reconstruction after total sacrectomy: A finite element analysis, Clinical Biomechanics, Volume 70, 2019, Pages 203-208.

Li X, Huang S, Wang C, Ji T#, Guo W#. Biomechanics Study of a 3D Printed SIJ Fixed Modular Hemipelvic Endoprosthesis. Clin Biomech (Bristol, Avon)(2nd Revision)

Chin BZ*, Ji T*, Tang X, Yang R, Guo W. Three-level lumbar en bloc spondylectomy with 3D-printed vertebrae reconstruction for recurrent giant cell tumor. World Neurosurg. 2019;129:531-537.e1

Yang K，Guo W，Ren T，Huang Y，Zhang H. Knockdown of HMGA2 regulates the level of autophagy via interactions between MSI2 and Beclin1 to inhibit NF1-associated malignant peripheral nerve sheath tumour growth. J EXP CLIN CANC RES 2019:38(1):185-185

Ren T，Guo W，Huang Y，Wang S，Bao X. Osteosarcoma cell intrinsic PD-L2 signals promote invasion and metastasis via the RhoA-ROCK-LIMK2 and autophagy pathways. Cell Death & Disease 2019,10(4):261-261

Han Yu，Guo Wei，Ren Tingting，et al. Tumor-associated macrophages promote lung metastasis and induce epithelial-mesenchymal transition in osteosarcoma by activating the COX-2/STAT3 axis.[J]Cancer Letters.2019,440-441:116-125

Wang Jun, Yangyi, Yang Rongli, Guo Wei. Does intramedullary nailing improve the union rate or decrease mechanical complications for patients with extremity sarcoma after biological reconstruction? Injury, 2019, 50(3):777-783

Wei R, Guo W, Yang R, Tang X, Yang Y, Ji T, Liang H.Reconstruction of the pelvic ring after total en bloc sacrectomy using a 3D-printed sacral endoprosthesis with re-establishment of spinopelvic stability: a retrospective comparative study. Bone Joint J.2019;101-B(7):880-888.

Wei R, Guo W, Yang R, Tang X, Yang Y, Ji T. Plate-prosthesis composite reconstruction after large segmental resection of proximal humeral tumors: A retrospective comparative study. Medicine. 2019;98(22):e15787.

Wei R, Dean DC, Thanindratarn P, Hornicek FJ, Guo W, Duan Z. Cancer Testis Antigens in Sarcoma: Expression, Function and Immunotherapeutic Application. Cancer Lett. 2019.

Xie, L., et al., Apatinib for Advanced Osteosarcoma after Failure of Standard Multimodal Therapy: An Open Label Phase II Clinical Trial. Oncologist, 2019;24:e542-e550.

Xie, L., et al., Gain and loss from transcatheter intra-arterial limb infusion of cisplatin for extremity osteosarcoma: a retrospective study of 99 cases in the past six years. Cancer Manag Res, 2019. 11: p. 7183-7195.

Guo W. Limb-salvage treatment of malignant pelvic bone tumor in China for past 20 years. Chin Med J (Engl). 2019;132(24):2994-2997.

Xu J, Xie L, Sun X,,Dong S,Tang X, Guo W. Management of recurrent or refractory Ewing sarcoma: A systematic review of phase II clinical trials in the last 15 years. ONCOLOGY LETTERS 18: 348-358, 2019

Wang Y, Liang W, Qu S, et al. Assessment of patient experiences following total sacrectomy for primary malignant sacral tumors: A qualitative study. J Surg Oncol. 2019;120(8):1497‐1504. doi:10.1002/jso.25756

Niu J, Yan T, Guo W, Wang W, Zhao Z. Insights into the roles of autophagy in osteosarcoma and therapeutic implications. Front. Oncol, 2019,9:1232. doi: 10.3389/fonc.2019.01232. (IF:4.137 )

Cai Z, Tang X , Yang R, Yan T, Guo W. ModifiedscorebasedonrevisedTokuhashiscoreisneededfor thedeterminationofsurgical interventionin patients with lung cancer metastases to the spine. World J Surg Oncol.2019,17(1):194.

王军,孙亦文,曲华毅,汤小东,杨毅,梁海杰,沈丹华,郭卫累及脊柱的RosaiDorfman病3例报告.中国脊柱脊髓杂志,2019,29(1):91-95.

3D-Printed Modular Hemipelvic Endoprosthetic Reconstruction Following Periacetabular Tumor Resection. J Bone Joint Surg, 2020

Xie, L., et al., Apatinib plus camrelizumab (anti-PD1 therapy, SHR-1210) for advanced osteosarcoma (APFAO) progressing after chemotherapy: a single-arm, open-label, phase 2 trial. J Immunother Cancer, 2020. 8(1).

Xie, L., et al., Anorexia, Hypertension, Pneumothorax, and Hypothyroidism: Potential Signs of Improved Clinical Outcome Following Apatinib in Advanced Osteosarcoma. Cancer Manag Res, 2020. 12: p. 91-102.

Xie, L., et al., Apatinib for Treatment of Inoperable Metastatic or Locally Advanced Chondrosarcoma: What We Can Learn About the Biological Behavior of Chondrosarcoma from a Two-Center Study. 1. Xie, L., et al., Cancer Manag Res, 2020. 12: p. 3513-3525.

Lim CY, Liu X, He F, et al. Retrospective cohort study of 68 sacral giant cell tumours treated with nerve-sparing surgery and evaluation on therapeutic benefits of denosumab therapy.Bone Joint J. 2020;102-B(2):177-185.

Xin Liang, Wei Guo, Tingting Ren, et al. Macrophages reduce the sensitivity of osteosarcoma to neoadjuvant chemotherapy drugs by secreting Interleukin-1 beta. Cancer Letters 480 (2020) 4-14.

全国各地天气预报查询

上海市

云南省

云南省

云南省

云南省

云南省